Question one The hypothetical data below are from a case control study of menopausal estrogen use and endometrial cancer, a type of cancer of the cervix. They pertain to women ages 55-59. Parity (number of births) = 0 or 1 Years of estrogen use Cases Controls 0-<1 30 20 1-4 70 20 5+ 100 10 Total 200 50 Parity = 2+ Years of estrogen use Cases Controls 0-<1 10 80 1-4 20 100 5+ 20 20 Total 50 200 1. Estimate the risk of endometrial cancer in women with 5 or more years of estrogen use relative to that in women with no or less than one year of use for : 1. Women with <=1 birth 2. Women with >=2 births All women 1. Is parity a confounding factor in evaluating the relationship between estrogen use and endometrial cancer ? If so, what is the parity adjusted relative risk associated with 5 or more years of estrogen use ? 2. What is the parity adjusted percentage of cases and controls who used estrogens for five or more years ? 3. Based on the above data alone, would you take parity into account if you were counselling menopausal women with intact uteri as to the hazards of estrogen use?
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[Answered]: Question one The hypothetical data below are…