[Expert Solution]: Jane C, is a 38 year old woman visiting her…

Jane C, is a 38 year old woman visiting her physician complaining of fatigue, fever, and joint pain. She also noticed sensitivity to the sun and reported having a rash following recent exposure. The lab results are shown: CBC Jane C. Reference Range (Adult Female) Urinalysis Jane C. Reference Range WBC count 3.5 5-10 x 109/L Color Yellow Yellow to Amber RBC count 3.5 4.0-15.0 x 1012/L Clarity Cloud/Froth Clear Hgb 10.5 12.0-16.0g/dL SG 1.022 1.004-1.035 HCT 32% 36-46% pH 7.0 5-7 MCV 91.7 80-100fL Protein 4+ Neg MCH 30 26-34pg Glucose Neg Neg MCHC 33 31-37g/dL Ketones Neg Neg RDW 12 11.4-14.5% Bilirubin Neg Neg ESR 40mm 0-10mm Blood 1+ Neg PLTS 100 150-400 Urobilinogen Normal Normal Differential Nitrite Neg Neg Neutrophils 85 25-60% Leuk. Ester. Neg Neg Bands 0 0-10% Microscopic Lymphocytes 13 20-50% WBC’s 0-3/HPF 0-5/HPF Monocytes 2 2-11% RBC’s 7-10/HPF 0-2/HPF Eosinophils 0 0-8% Epthelial Rare Few to Moderate Basophils 0 0-2% Casts Rare renal, 0-3 hyaline 0-1 RBC 0-1 gran. 0-1 waxy Few Hyaline Morphology Normal Serology Tests Jane C. Reference Range Antinuclear Antibody Positive 1:160; Homogeneous Negative Rheumatoid Factor <1_10 <1_80 RPR Weakly Reactive Non-reactive FTA-ABS (syphilis antibodies) Weakly Reactive Non-reactive CRP 3.10 Non-reactive Complement C3 50 83-177mg/dL Complement C4 20 29-68mg/dL IgG 3020 565-1765mg/dL IgM 420 50-300mg/dL 1. Based on Jane C.’s physical symptoms only, list two conditions that should need to be ruled out (or in). (2) 2. After reviewing the results of the lab results, which diagnosis is more probable? Why? (2) 3. Briefly describe the pathophysiology of this disease. What is happening in Jane’s body? What part(s) of her body have been affected so far? (2) 4. If the RF were positive, would you change your answer to question 2? Why or why not? (2) 5. List 5-6 criteria proposed by the American College of Rheumatology for diagnosis this condition. (5) 6. Which of the ANA patterns (or tests) are considered specific for this condition? (1) Speckled 7. What is the significance of the syphilis serology result? (1) 8. Are the complement levels consistent with your diagnosis? If yes, why? (2)