[Verified Answer]: DJ is a 40 year old male who is receiving…

DJ is a 40 year old male who is receiving valproic acid for the prophylactic treatment of migraine headaches. While the drug has effectively reduced the frequency and severity of his headaches, he continues to experience one or two severe episodes monthly. DJ has been asked to participate in a clinical trial of a new drug that would be added to his regimen of valproic acid. Studies in vitro show that this investigational drug can displace valproic acid from plasma protein binding sites. Below are some average pharmacokinetic parameters for valproic acid in adults