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[Solved]: Discuss THREE advantages of DPIs compared to MDIs

Discuss THREE advantages of DPIs compared to MDIs. [3 marks] Explain how the use of the spacer with the inhaler may reduce the side effect of throat thrush. Your answer should use the relevant equation of deposition. [3 marks] MDIs need to deliver the drug as an aerosol using liquified propellent at a pressure around 450 kPa at 20deg C. Calculate the mole percentage of HFA-134 (Po = 660 kPa at 20deg C) and HFA-227 (Po = 398 kPa at 20deg C) required to achieve the pressure of 450 kPa. [4 Marks]

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