[Solved]: A 20-year-old, 60-kg female patient with end-stage…

A 20-year-old, 60-kg female patient with end-stage renal failure receives a 250-mg oral dose of a Drug X twice daily. The elimination half-life of the drug for this patient is approximately 12 hours. The patient undergoes 6 hours of hemodialysis every week. The patient is advised to take the medication at 8 AM and 8 PM. The weekly dialysis starts at 12 noon and ends at 6 PM. The volume of distribution of the drug is 12 L, the absorption rate constant is 5.98/h, and the bioavailability is 1. The rate constant of dialysis (itself) is 0.2/h. Calculate: 1. Peak and trough plasma level at steady state (without dialysis). 2. Plasma concentration at 6 PM on the day of dialysis. 3. A replenishment dose to attain the peak level at 8 PM