[Expert Solution]: Dr

Dr. Sariles Rasmussen would like to study the effect of chlorine exposure on the risk of asthma. Although asthma is a very common disease, chlorine exposure is rare. Which study design is most appropriate? [Choose the ONE best answer] A. Enroll a cohort of 10,000 chlorine plant workers and compare their incidence of asthma over the next three months with a cohort of 10,000 workers not exposed to chlorine. B. Enroll 100 asthma patients and match them (1:4) with 400 healthy controls of the same age, sex, and race, then ask the cases and controls about their chlorine exposure. C. Set up a randomized clinical trial in which 500 subjects will be exposed to chlorine, and compare their incidence of asthma with 500 other subjects who are exposed to ammonia instead D. None of the above