[Expert Solution]: Circle the correct answer only

Circle the correct answer only. 1.1 Pharmacogenetic testing will not A. identify drug/drug interactions B. predict toxicity to a drug C. predict response to a drug D. distinguish rapid from slow metabolizers E. guide drug and dose selection 1.2 Results describing the phenotype or genotype of TPMT are useful for dosing the following drug: A. irinotecan B. amitriptyline C. azathioprine D. atomoxetine E. cisplatin 1.3 Interpretation of CY2D6 genotyping results depends on all of the following EXCEPT A. how the CY2D6 variant(s) detected by the assay affects enzyme function B. the age of the patient C. the presence or absence of gene duplication D. the specific variants detected by the genotyping assay E. the number of variant alleles detected 1.4 The dosing of a prodrug may be affected by pharmacogenetic results because A. PMs may require lower doses of the prodrug than EMs B. PMs may require a different drug than EMs C. EMs may require higher doses of the prodrug than EMs D. PMs may require lower doses of the prodrug than IMs E. UMs may require higher doses of the prodrug than EMS (* PM = poor metabolizer, IM = intermediate metabolizer, EM = extensive metabolizer, UM = ultra-rapid metabolizer) 1.5 What is the most common form of polymorphism? A. inversion B. deletion C. repeats D. single nucleotide E. splicing