[Expert Solution]: A 32-year-old woman with systemic lupus…

A 32-year-old woman with systemic lupus erythematosus (SLE) experiences joint pain and swelling that is accompanied by impaired compression/deformation abilities of her cartilage. Which of the following best deseribes the impaired extracellular matrix component and the impact it has on cartilage in this patient with SLE? Elastin of SLE cartilage is unable to stretch so cartilage cannot expand Excess collagen in SLE cartilage causes joint stiffening Laminin-mediated adhesion is interrupted, making SLE cartilage more diffuse Reduced proteoglycan leads to impaired resilience of SLE cartilage