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[Answered]: A 28-year-old woman bleeds profusely after the…

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A 28-year-old woman bleeds profusely after the birth of her first child. She has had a mild systemic bleeding tendency (after hemostatic challenges) throughout her life. PT: 12.8 sec aPTT: 42.9 sec PLT: 208  109/L 1. Interpret the coagulation screening tests. Note: Because disseminated intravascular coagulopathy (DIC) is a common bleeding disorder in obstetric patients, fibrinogen and D-dimer assays would probably be ordered to rule out this disorder even though the screening results are not consistent with it. The results of additional studies were as follows: Fibrinogen: 256 mg/dL D-dimer: 0.3 g/mL Factor VIII assay: 40% activity Bleeding time: 28 min PLT aggregation: absence of aggregation in response to ristocetin VWF antigen: 35% VWF activity: 30% 2. Considering all the data provided, what condition is most likely? 3. What information is most diagnostic?

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