[Expert Solution]: A 2-year-old boy with no known medical…

A 2-year-old boy with no known medical illness weighing 11.6 kg was admitted for multiple bruises for a one-week duration due to thrombocytopenia. A diagnosis of immune thrombocytopenic purpura was made. He was started on intravenous immunoglobulin at 1 mg/kg dose and indicated for two units of whole blood (WB) derived platelet transfusion in view of bleeding manifestation and very severe thrombocytopenia with platelet level of 3 × 109/L. The patient is B Rhesus D (RhD) positive and received O RhD positive WB derived platelets due to the unavailability of blood group B platelets. He developed chills, rigours and shortness of breath during the second unit of platelet transfusion. He deteriorated with oxygen saturation of 80% under room air, hypotensive (94/56 mmHg), tachycardia (156 beats/minute), and tachypnea (26 breath/minute) with a temperature of 38 ◦C. His haemoglobin (Hb) dropped to 8.2 g/dl from 10.2 g/dl supported with blood film evidence of spherocytosis and small agglutinations . He had slight jaundice and elevated lactate dehydrogenase (LDH) levels of 1209 U/L. His erythrocytes demonstrated a positive Direct Antiglobulin Test (DAT). Suggest a potential diagnosis of the condition manifested, how you could confirm this diagnosis and indicate a possible cause for these symptoms